Aorticopulmonary septum
| Aorticopulmonary septum |
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| Diagrams to show the development of the septum of the aortic bulb and of the ventricles. |
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| Transverse sections through the aortic bulb to show the growth of the aortic septum. The lowest section is on the left, the highest on the right of the figure. |
| Latin |
septum aorticopulmonale |
| Gray's |
subject #135 514 |
| Days |
37 |
| Precursor |
neural crest |
| Code |
TE E4.0.3.5.0.3.12 |
The aorticopulmonary septum (also called the spiral septum, or aortic septum in older texts) is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development.[1][2]
The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. Malalignment of the septum can cause the congenital heart condition Tetralogy of Fallot.
See also
References
- ^ Kirby ML, Gale TF, and Stewart DE. (1983). "Neural crest cells contribute to normal aorticopulmonary septation.". Science 220 (4061): 1059–61. doi:10.1126/science.6844926. PMID 6844926.
- ^ Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM.. (2000). "Fate of the mammalian cardiac neural crest...". Development (Cambridge, England) 127 (8): 1607–16. PMID 10725237.
External links
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Vasculogenesis,
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anuli: Anulus sanguineus perienameleus · lacunae: Lacuna sanguinea supraenamelea (Ductus sanguineus mesialis · Ductus sanguineus distalis · Ductus sanguineus lingualis · Ductus sanguineus palatinus · Ductus sanguineus buccalis · Ductus sanguineus labialis), Lacuna sanguinea apicalis, Lacuna sanguinea periodontalis, Lacuna sanguinea parodontalis, Lacuna sanguinea gingivalis
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